Adherent-invasiveEscherichia colitarget the epithelial barrier
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چکیده
منابع مشابه
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens. Inflammation plays a critical role in altering the epithelial barrier and is a major factor involved in promoting the expansion and pathogenesis of AIEC. AIEC in ...
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The simplest multicellular animal organisms, coelenterates, are essentially floating intestines in the sea. More fundamentally, they are ‘barrier tubes’ that attempt to compartmentalize the environment they exist in. It is said that ontogeny recapitulates phylogeny. It is thus interesting that the blastocyst, among the earliest multicellular embryonic structures, is essentially a sac comprised ...
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Alveolar lining fluid normally contains proteins of important physiological, antioxidant, and mucosal defense functions [such as albumin, immunoglobulin G (IgG), secretory IgA, transferrin, and ceruloplasmin]. Because concentrations of plasma proteins in alveolar fluid can increase in injured lungs (such as with permeability edema and inflammation), understanding how alveolar epithelium handles...
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In celiac disease (CD) a T-cell-mediated response to gluten is mounted in genetically predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted by villous atrophy and crypt hyperplasia. Recent data point to the epithelial layer as an under-rated hot spot in celiac pathophysiology to date. This overview summarizes current functional and genetic evidence on the ...
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The closure of gaps within epithelia is crucial to maintain its integrity during biological processes such as wound healing and gastrulation. Depending on the distribution of extracellular matrix, gap closure occurs through assembly of multicellular actin-based contractile cables or protrusive activity of border cells into the gap. Here we show that the supracellular actomyosin contractility of...
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ژورنال
عنوان ژورنال: Gut Microbes
سال: 2010
ISSN: 1949-0976,1949-0984
DOI: 10.4161/gmic.1.2.11142